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HtrA1 protein expression (immunohistochemistry). (A) Lack of HtrA1 expression in the normal macula of a human eye; (B) Increased HtrA1 expression (black color) is noted in drusen (open arrow) and abnormal retinal pigment epithelium cells (arrows) of an eye with atrophic age-related macular degeneration; (C) choroidal neovascular vessel structure (arrows) of an eye with neovascular age-related macular degeneration. (R, retina; C, choroid; avidin-biotin complex immunoperoxidase)
