. Author manuscript; available in PMC: 2009 Nov 1.

Published in final edited form as: Ophthalmology. 2008 Aug 21;115(11):1891–1898. doi: 10.1016/j.ophtha.2008.05.021

Table 4.

Combined Effect (Odds Ratios (OR), 95% Confidence Intervals (CI)) of the HtrA1 Promotor SNP and the CFH SNP on Age-related Macular Degeneration Risk from All Pooled Samples from the Four Sample Sets

HtrA1	CFH
	Unadjusted OR (95% CI)			Age, sex adjusted OR (95% CI),
	GG	GC	CC	GG	GC	CC
GG	1	0.84	1.98	1	0.82	2.03
GG		(0.56, 1.25)	(1.23, 3.21)		(0.54, 1.24)	(1.23, 3.35)
GA	1.00	1.73	5.17	0.97	1.74	5.07^**
GA	(0.61, 1.66)	(1.15, 2.61)	(2.98, 8 97)	(0.58, 1.62)	(1.13, 2.67)	(2.87, 8.94)
AA	1.37	6.07	Not available	1.22	5.36^*	Not available
AA	(0.65, 2.88)	(2.80, 13.14)		(0.56, 2.66)	(2.44, 11.81)

SNP type AA GC with respect to SNP types AA GG & GA GC combined: p=0.0001

^**

SNP type GA CC with respect to SNP types GG CC & GA GC combined: p=0.0008