Skip to main content
. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Ophthalmology. 2008 Aug 21;115(11):1891–1898. doi: 10.1016/j.ophtha.2008.05.021

Table 5.

Combined Effect, (Odds Ratios, 95% Confidence Intervals) of HtrA1 Promotor SNP and Smoking Status on the Risk of Age-related Macular Degeneration

HtrA1 Genotype
GG GA AA
Smoking Status Never Smoked 1.00 1.80 (1.40, 2.32) 3.54 (2.25, 5.56)
Ever Smoked 1.70 (1.25, 2.30) 3.55 (2.61, 4.85)* 17.71(7.49, 41.88)**
Cholesterol Normal 1.00 2.17 (1.41, 3.34) 6.89 (3.03, 15.66)
High 1.23 (0.85, 1.76) 2.41 (1.65, 3.50) 4.86 (2.70, 8.74)
*

p=8.73×10−4 in comparison with Never Smoked with SNP type GA

**

p=1.17×10−3 in comparison with Never Smoked with SNP type AA