. Author manuscript; available in PMC: 2009 Sep 1.

Published in final edited form as: Int J Radiat Oncol Biol Phys. 2008 Sep 1;72(1):278–287. doi: 10.1016/j.ijrobp.2008.05.014

Table 1.

Medians and ranges of endpoint values in the IMRT and the two- and three-beam proton plans

Endpoint	IMRT [Median (min, max)]	Two-Beam Proton Therapy	P Value vs IMRT	Three-Beam Proton Therapy	P Value vs IMRT
Conformity index	1.55 (1.44, 1.68)	1.99 (1.79, 2.28)	0.001	1.46 (1.36, 1.71)	0.006
Lung
V5, %	49.5 (34.3, 65.1)	13.9 (6.9, 21.4)	0.001	32.1 (21.2, 41.6)	0.001
V10, %	32.5 (21.1, 49.3)	12.0 (5.7, 18.7)	0.001	24.1 (11.0, 35.8)	0.001
V20, %	15.6 (9.54, 26.3)	9.79 (4.34, 15.6)	0.001	10.6 (5.47, 16.5)	0.001
V30, %	7.08 (3.23, 10.88)	7.17 (2.78, 13.24)	1.000	6.61 (3.15, 10.4)	0.053
Mean dose, cGy	965.0 (680.4, 1305.36)	453.3 (201.6, 740.88)	0.001	664.6 (438.5, 937.4)	0.001
VS5, cm³	1815 (643, 2491)	3053 (1553, 4306)	0.001	2532 (1233, 3225)	0.001
VS10, cm³	2598 (933, 3216)	3096 (1596, 4433)	0.001	2834 (1508, 3475)	0.001
VS20, cm³	3024 (1357, 4260)	3150 (1644, 4584)	0.001	3102 (1652, 4508)	0.001
VS30, cm³	3226 (1697, 4741)	3271 (1688, 4836)	0.57	3277 (1708, 4859)	0.05

Cord, maximum dose, cGy	4107 (3691, 4349)	4035 (2963, 4480)	0.865	2563 (1053, 3971)	0.001
Heart
V40, %	35.7 (16.7, 55.3)	41.8 (24.7, 66.2)	0.02	27.7 (13.9, 51.7)	0.002
V50, %	15.0 (7.07, 25.0)	28.6 (17.1, 46)	0.001	15.9 (8.2, 31.4)	0.125

Total body, mean dose, cGy	905.2 (599.8, 1315.44)	571.9 (322.6, 972.7)	0.001	587.3 (342.7, 932.4)	0.001

IMRT, intensity-modulated (photon) radiation therapy; V5. volume (of lung) exposed to 5 Gy or more; VS5, volume (of lung) spared from exposure of 5 Gy or more.