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. Author manuscript; available in PMC: 2009 Nov 15.
Published in final edited form as: Cell. 2008 Nov 14;135(4):623–634. doi: 10.1016/j.cell.2008.09.058

Figure 1. Structure of DnaCAAA+.

Figure 1

(A) Domain representation of DnaC. The N-terminal helicase binding region is colored gray and the central AAA+ domain is shown in red. Numbers refer to amino acid positions. AAA+ motifs are highlighted. WA – Walker-A, WB – Walker-B, SI – sensorI, SII – sensor-II, ISM – Initiator Specific Motif.

(B) Sequence alignment of selected DnaC and DnaA homologs. Alignment was generated by ClustalX (Thompson et al., 1997).

(C) Stereo view of DnaCAAA+. Walker-A and -B motifs are blue and yellow, respectively. The sensor-I residue is green and the Box VII helix cyan. ADP and the coordinating magnesium ion (black) are shown within the ATP binding cleft. An internal disordered region is shown as a dotted line. This and all other molecular figures were generated with PyMOL (pymol.sourceforge.net).