Table 2.
Expression of EBV and Topo II∝ in the normal oral tissues, oral epithelial dysplasia and oral squamous cell carcinomas
| HISTOLOGY | Number of cases | EBV expression(%)(a) | P-value | Topo II-∝ LI (%)(b) | P-value |
| NSE | 20 | 0.000 ± 0.000 | d | 5.35 ± 2.22 | c |
| OED | 16 | 25.6 ± 25.38 | 14.08 ± 2.99 | ||
| Mild | 7 | 13.43 ± 13.24 | NS | 12.27 ± 2.17 | NS |
| Moderate | 5 | 24.00 ± 22.62 | 13.50 ± 1.86 | ||
| Severe | 4 | 48.75 ± | 17.98 ± 1.51 | ||
| OSCC | 22 | 41.79 ± 29.31 | 27.56 ± 7.49 | ||
| W-scc | 10 | 36.09 ± 22.37 | 22.40 ± 3.19 | ||
| M-scc | 8 | 41.15 ± 33.18 | NS | 28.54 ± 4.84 | e |
| P-scc | 4 | 57.33 ± 38.91 | 39.00 ± 6.45 |
NSE, normal squamous epithelium; OED, OraLepithelial dysplasia; OSCC, oral squamous cell carcinoma; NS, not significant.
a mean ± standered deviation of EBV
b mean ± standered deviation of Topo II-α LI.
c NSE vs. OED P < 0.001;NSE vs. SCC, P < 0.001; OED vs. SCC, P = 0.083.
dNSE vs. OED P < 0.001;NSE vs. SCC, P < 0.001; OED vs. SCC, P < 0.001.
eW-SCC vs. M-SCC, P = 0.008; W-SCC 1 vs.P-SCC, P = 0.001; W-SCC vs. M-SCC +P-SCC, P < 0.001.