Table 4.
Prognostic Factors of OS in Multivariate Analysis Using AFT and Cox's Models (n = 206).
| Weibull AFT | Cox PH | Cox with time-varying coefficients | ||||
| Characteristics | Time ratio(95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value |
| Relapse(yes vs. no) | .082(.039 .17) | < .001 | 5.2(3.1 8.94) | < .001 | .69(.25 1.8) | .062 |
| aGVHD(yes vs. no) | .95(.45 2.03) | .91 | 1.09(.61 1.95) | .76 | .96(.53 1.74) | .90 |
| cGVHD(yes vs. no) | 1.52(.62 3.72) | .35 | .71(.35 1.43) | .34 | .16(.04 .62) | .008 |
| Platelet recovery(yes vs. no) | 2.37(1.05 5.32) | .037 | .52(.28 .96) | .039 | .53(.28 1.03) | 062 |
| Neutrophil recovery(yes vs. no) | 2.71(.62 11.85) | .184 | .46(.14 1.44) | .187 | .39(.12 1.24) | .12 |
| Ti *cGVHD | 1.006(1.002 1.011) | .003 | ||||
| Ti *relapse | 1.012(1.006 1.019) | < .001 | ||||
| Explained variation(R2) | .46 | .21 | .34 | |||
aGVHD; acute graft-versus-host disease, cGVHD; chronic graft-versus-host disease, AFT; accelerated failure time, PH; proportional hazard, HR; hazard ratio, Ti; survival time.
Note: the corresponding regression coefficients in the above models can be obtained by taking logarithm of time ratio and hazard ratio.