Fig. 1.

Comparison of serum responses to injected and inhaled vaccination with 23-valent pneumococcal capsular polysaccharide vaccine. IgG (left hand graphs) and IgA (right hand graphs) specific to pneumococcal capsular types 1, 9V and 14 are shown before and 1 month after vaccine. The box (25–75%) and whisker (5–95%) graphs with outlying values show median values for each group on a log scale. Following injected vaccine, a significant increase in serum IgG to all three capsular polysaccharide types tested was seen at 1 month. There was a significant increase seen in type 1 IgA only. Following inhaled vaccine, there was no significant increase in any serum parameter but there was a significant drop in both IgG and IgA to type 9V.