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. 2008 Oct 3;26(42):5400–5406. doi: 10.1016/j.vaccine.2008.07.082

Fig. 2.

Fig. 2

Comparison of bronchoalveolar lavage (BAL) responses to injected and inhaled vaccination with 23-valent pneumococcal capsular polysaccharide vaccine. IgG (left hand graphs) and IgA (right hand graphs) specific to pneumococcal capsular types 1, 9V and 14 were tested in BAL at baseline and 1 month after vaccine. The box (25–75%) and whisker (5–95%) graphs with outlying values show median values for each group on a log scale. Following injected vaccine, a significant increase in BAL IgG to all three capsular polysaccharide types tested was seen at 1 month. There was no significant increase in BAL IgA. Following inhaled vaccine, there was no significant increase in any serum parameter but there was a significant drop in BAL IgA to type 9V.