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Elution profile with the optimized formulation of PMMA-xylitol for the elution of daptomycin. Samples from PMMA beads containing 2 g of daptomycin and 22 g of xylitol per 40-g packet of PMMA were assayed by HPLC (⋄) or bioassay (⧫). Results are reported as the averages ± standard deviations from six replicates. The upper dashed line indicates the 100× threshold (100 μg/ml), while the lower dashed line indicates the 5× threshold (5 μg/ml).
