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. 2008 Oct 27;53(1):186–192. doi: 10.1128/AAC.00333-08

FIG. 3.

FIG. 3.

In vivo efficacy of the prodrug of R-125489 with acyl chains of various lengths in a mouse influenza virus infection model. Influenza A virus A/PR/8/34-infected (1,500 PFU, 0 h) mice given 0.3 μmol/kg of R-125489-C8 (CS-8958, filled squares), R-125489-C10 (filled triangles), R-125489-C6 (open triangles), R-125489-C4 (open squares), zanamivir (filled circles), and saline (open circles) (a) or R-125489-C8 (CS-8958, filled squares), R-125489-C10 (filled triangles), R-125489-C14 (open triangles), R-125489-C16 (open squares), zanamivir (filled circles), and saline (open circles) (b) at 4 h before infection and 4 h and 17 h p.i. The number of surviving mice was monitored for 20 days p.i. (n = 10 to 12).