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. 2008 Oct 27;53(1):186–192. doi: 10.1128/AAC.00333-08

TABLE 1.

IC50s and 95% CIs of NA activities against human influenza virusesc

Influenza virusa Virus subtype or lineage Strain typeb CS-8958
R-125489
Zanamivir
Oseltamivir carboxylate
IC50 (nM) 95% CI IC50 (nM) 95% CI IC50 (nM) 95% CI IC50 (nM) 95% CI
H1N1 viruses
    A/Puerto Rico/8/1934 H1N1 LS 931 829-1,050 5.97 4.88-7.69 3.62 3.08-4.30 2.39 1.96-2.95
    A/Yamagata/32/1989 H1N1 VS 882 776-998 3.42 2.94-4.01 2.55 1.96-3.67 1.54 1.28-1.91
    A/New Caledonia/20/1999 H1N1 VS 666 589-756 2.32 1.85-2.95 2.05 1.68-2.65 1.58 1.35-1.90
    A/Shiga/1/2002 H1N1 CI 733 630-860 2.09 1.39-3.45 1.63 1.15-2.40 1.34 1.05-1.72
    A/Yamagata/3/2002 H1N1 CI 709 592-858 2.57 1.93-3.55 1.68 1.36-2.06 1.08 0.944-1.23
    A/Yamagata/57/2002 H1N1 CI 1,170 1,040-1,320 1.65 1.39-2.02 1.14 0.832-1.70 0.658 0.575-0.756
    A/Saitama/78/2003 H1N1 CI 940 756-1,170 1.79 1.26-2.55 1.38 1.03-1.99 1.12 0.775-1.71
    A/Aichi/193/2004 H1N1 CI 983 792-1,220 2.63 2.32-3.08 1.17 0.796-2.00 1.26 0.789-2.54
    A/Okinawa/42/2004 H1N1 CI 631 533-750 2.07 1.33-4.09 0.751 0.527-1.13 1.86 1.69-2.05
    A/Aichi/169/2005 H1N1 CI 664 545-817 1.55 1.06-2.38 1.19 0.798-2.06 1.12 0.780-1.81
    A/Yamagata/83/2006 H1N1 CI 733 668-808 1.29 0.910-2.06 0.880 0.686-1.17 0.785 0.660-0.945
    Mean ± SD 822 ± 171 2.49 ± 1.30 1.64 ± 0.838 1.34 ± 0.491
H2N2 virus
    A/Singapore/1/1957 H2N2 LS 128 107-152 11.4 9.14-14.4 3.66 2.98-4.56 0.925 0.831-1.03
H3N2 virus
    A/Aichi/2/1968 H3N2 LS 164 149-179 16.8 13.9-21.1 7.33 5.75-10.2 2.39 1.83-3.48
    A/Kitakyushu/159/1993 H3N2 VS 221 205-239 23.5 18.9-31.3 9.30 8.40-10.3 1.60 1.14-2.60
    A/Wyoming/03/2003 H3N2 VS 114 99.5-129 22.2 17.9-28.0 11.0 9.50-12.9 1.71 1.34-2.34
    A/Wellington/1/2004 H3N2 VS 157 132-183 26.8 23.9-30.9 8.74 7.47-10.2 1.99 1.92-2.06
    A/California/07/2004 H3N2 VS 135 121-150 19.4 15.7-25.6 8.21 6.32-11.8 1.90 1.47-2.69
    A/New York/55/2004 H3N2 VS 136 125-147 19.2 15.3-25.9 7.35 5.68-10.5 1.56 1.18-2.28
    A/Hiroshima/52/2005 H3N2 VS 69.1 62.5-76.7 12.7 11.1-14.6 5.11 4.32-6.24 1.33 1.18-1.51
    A/Wisconsin/67/2005 H3N2 VS 187 171-206 38.8 33.4-45.5 14.2 11.9-17.2 3.44 3.16-3.75
    A/Shiga/5/2002 H3N2 CI 64.2 51.5-78.9 10.1 9.29-11.0 4.82 4.06-5.88 0.706 0.597-0.843
    A/Yamagata/1/2002 H3N2 CI 56.6 45.5-69.1 14.2 12.2-16.6 7.58 6.07-10.1 1.09 0.981-1.22
    A/Yamagata/2/2002 H3N2 CI 46.6 40.8-53.0 7.09 5.36-9.62 6.45 5.08-8.87 0.981 0.880-1.09
    A/Saitama/80/2003 H3N2 CI 39.2 31.5-48.0 10.4 7.57-15.3 7.16 4.86-13.8 0.711 0.550-0.940
    A/Osaka/56/2004 H3N2 CI 129 118-141 8.72 6.96-11.2 4.84 4.07-5.93 1.08 0.836-1.48
    A/Tokushima/1/2005 H3N2 CI 131 117-147 7.54 5.76-11.0 3.42 3.02-3.88 0.925 0.742-1.19
    A/Saitama/07/2006 H3N2 CI 63.3 52.8-75.0 13.0 11.2-15.3 6.04 5.01-7.62 0.885 0.716-1.12
    Mean ± SD 114 ± 55.5 16.7 ± 8.62 7.44 ± 2.70 1.49 ± 0.738
Type B
    B/Brisbane/32/2002 Victoria VS 9,890 8,880-11,000 30.5 26.2-35.5 7.78 6.29-9.83 13.6 12.2-15.1
    B/Malaysia/2506/2004 Victoria VS 11,100 10,400-11,900 31.3 28.7-34.0 8.66 6.94-11.1 15.1 13.6-16.7
    B/Ohio/01/2005 Victoria VS 12,800 11,800-13,900 30.0 27.6-32.7 7.86 6.45-9.75 13.6 11.9-15.5
    B/Shiga/17/2002 Victoria CI 7,680 6,980-8,490 18.2 16.9-19.6 7.11 5.45-10.3 8.72 5.99-11.8
    B/Yamagata/15/2002 Victoria CI 6,980 6,310-7,760 15.9 13.6-19.2 5.68 4.48-7.72 7.25 5.81-8.94
    B/Akita/9/2003 Victoria CI 13,800 12,400-15,600 12.4 10.8-14.5 3.79 3.35-4.33 9.55 8.04-11.3
    B/Tokushima/1/2003 Victoria CI 13,800 12,600-15,200 11.4 10.1-13.0 3.55 3.12-4.07 9.26 7.77-11.0
    B/Yamagata/145/2003 Victoria CI 15,900 13,900-18,300 10.4 7.86-14.7 4.05 3.44-4.84 3.09 2.83-3.37
    B/Yamagata/398/2003 Victoria CI 12,400 11,700-13,200 12.5 11.1-14.2 3.78 3.33-4.32 10.1 8.53-12.0
    B/Aichi/3/2006 Victoria CI 13,800 12,900-14,900 19.3 16.0-24.4 4.85 4.19-5.71 12.4 11.0-14.0
    B/Saitama/01/2006 Victoria CI 45,500 42,000-49,800 26.5 19.9-40.2 6.41 5.16-8.46 13.7 11.7-16.0
    B/Mie/1/1993 Yamagata VS 6,850 6,150-7,610 31.3 28.2-34.8 12.0 10.6-13.6 15.6 14.2-17.1
    B/Shanghai/361/2002 Yamagata VS 6,660 5,920-7,470 31.4 28.6-34.6 10.1 7.76-13.9 12.0 10.5-13.6
    B/Shiga/31/2002 Yamagata CI 10,500 10,000-11,100 14.0 12.1-16.4 4.90 4.08-6.08 9.16 7.61-11.0
    B/Shizuoka/58/2004 Yamagata CI 7,530 6,850-8,310 16.0 13.6-19.4 5.67 4.66-7.24 8.34 7.06-9.81
    B/Yamagata/85/2004 Yamagata CI 7,190 6,610-7,830 18.3 15.4-22.7 6.44 5.25-8.33 8.84 7.51-10.4
    B/Yamagata/87/2004 Yamagata CI 7,790 7,470-8,110 16.7 14.0-20.4 5.82 4.86-7.26 8.26 6.95-9.78
    B/Aichi/186/2005 Yamagata CI 3,550 3,160-3,980 15.0 12.8-18.1 6.72 5.45-8.79 9.21 8.02-10.6
    B/Saitama/01/2005 Yamagata CI 3,610 3,200-4,080 15.0 13.2-17.5 6.89 5.49-9.28 10.6 9.25-12.2
    B/Sapporo/29/2005 Yamagata CI 3,600 3,140-4,120 15.4 13.3-18.2 6.91 5.40-9.64 9.62 8.27-11.2
    B/Tokushima/1/2005 Yamagata CI 3,710 3,260-4,240 14.2 12.2-16.8 6.30 5.18-8.04 8.35 7.16-9.71
    B/Yamagata/1/2005 Yamagata CI 3,630 3,190-4,140 13.7 11.9-16.2 6.36 5.11-8.45 9.44 7.86-11.3
    B/Yamagata/113/2005 Yamagata CI 3,500 3,130-3,910 15.8 13.5-19.0 7.59 5.91-10.7 10.6 9.17-12.3
    Mean ± SD 10,100 ± 8,670 18.9 ± 7.20 6.49 ± 2.02 10.3 ± 2.82
a

Means and standard deviations (SD) of NA inhibitor compound IC50s to H1N1 (11 strains), H3N2 (15 strains), and type B viruses (23 strains) are shown.

b

LS, laboratory strain; VS, vaccine strain; CI, clinical isolate.

c

Maximum and minimum IC50s of each compound against H1N1, H3N2, and type B viruses are underlined. IC50s of NA inhibitors to B viruses in boldface indicate maximum or minimum IC50s of each inhibitor to the clinical isolates. CI, confidence interval.