TABLE 2.
IC50s and 95% CIs of NA activities against animal influenza virusesb
| Influenza virus | Subtype | CS-8958
|
R-125489
|
Zanamivir
|
Oseltamivir carboxylate
|
||||
|---|---|---|---|---|---|---|---|---|---|
| IC50 (nM) | 95% CI | IC50 (nM) | 95% CI | IC50 (nM) | 95% CI | IC50 (nM) | 95% CI | ||
| A/R(duck/Mongolia/54/01- duck/Mongolia/47/01)a | H5N1 | 276 | 254-300 | 4.54 | 3.91-5.37 | 2.99 | 2.25-4.20 | 2.17 | 1.94-2.43 |
| A/duck/Hokkaido/84/2002 | H5N3 | 456 | 413-502 | 13.3 | 11.6-15.6 | 3.65 | 2.63-5.57 | 2.94 | 2.80-3.10 |
| A/turkey/Ontario/6,118/1968 | H8N4 | 420 | 378-471 | 7.08 | 6.55-7.71 | 5.58 | 4.35-7.71 | 3.65 | 2.99-4.37 |
| A/duck/Alberta/60/1976 | H12N5 | 1,140 | 1,020-1,270 | 2.34 | 2.24-2.44 | 1.83 | 1.49-2.35 | 1.43 | 1.31-1.55 |
| A/duck/England/1/1956 | H11N6 | 262 | 242-282 | 25.5 | 24.9-26.3 | 8.57 | 8.11-9.06 | 2.81 | 2.70-2.92 |
| A/seal/Massachusetts/1/1980 | H7N7 | 142 | 121-165 | 27.9 | 25.9-30.1 | 11.5 | 10.5-12.6 | 2.56 | 2.42-2.72 |
| A/duck/Ukraine/1/1963 | H3N8 | 1,050 | 1,010-1,090 | 1.81 | 1.77-1.84 | 1.40 | 1.24-1.61 | 2.12 | 1.93-2.34 |
| A/duck/Memphis/546/1974 | H11N9 | 356 | 313-403 | 6.81 | 6.51-7.14 | 3.31 | 3.11-3.53 | 1.70 | 1.66-1.73 |
a
Reassortant virus generated from A/duck/Mongolia/54/01 (H5N2) and A/duck/Mongolia/47/01 (H7N1).
b
Maximum and minimum IC50s are underlined for each compound. CI, confidence interval.