TABLE 3.
IC50s, 95% CIs, and mutant/wild-type ratios of NA activities against oseltamivir-resistant influenza virusesb
| Influenza virus | Virus type or subtype | Mutation in NAa | R-125489
|
Zanamivir
|
Oseltamivir carboxylate
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 (nM) | 95% CI | Ratio | IC50 (nM) | 95% CI | Ratio | IC50 (nM) | 95% CI | Ratio | |||
| A/Yokohama/67/2006 (clone 1) | H1N1 | WT | 3.03 | 2.75-3.35 | 2.70 | 2.53-2.90 | 2.28 | 2.12-2.43 | |||
| 1.9 | 1.1 | 330 | |||||||||
| A/Yokohama/67/2006 H274Y (clone 11) | H1N1 | H274Y | 5.62 | 4.75-6.89 | 3.05 | 2.88-3.23 | 755 | 727-784 | |||
| A/Kawasaki/IMS22A-954/2003 | H3N2 | WT | 15.4 | 13.4-18.0 | 8.29 | 7.87-8.72 | 1.25 | 1.09-1.45 | |||
| 0.69 | 1.4 | 8,400 | |||||||||
| A/Kawasaki/IMS22B-955/2003 | H3N2 | R292K | 10.6 | 9.83-11.4 | 11.2 | 9.59-13.0 | 10,400 | 9,600-11,400 | |||
| A/Yokohama/IMS9A-2029/2003 | H3N2 | WT | 19.2 | 15.9-24.2 | 10.7 | 10.1-11.4 | 1.78 | 1.76-1.80 | |||
| 0.69 | 0.72 | 79 | |||||||||
| A/Yokohama/IMS9B-2050/2003 | H3N2 | E119V | 13.2 | 11.7-15.0 | 7.71 | 7.58-7.85 | 140 | 120-165 | |||
| A/Kawasaki/MS31A-1030/2002 | H3N2 | WT | 13.4 | 11.8-15.3 | 7.82 | 7.57-8.10 | 1.18 | 1.07-1.31 | |||
| 2.8 | 1.7 | 32 | |||||||||
| A/Kawasaki/MS31B-1206/2002 | H3N2 | N294S | 37.3 | 33.9-41.2 | 13.5 | 12.0-15.4 | 37.2 | 34.7-39.7 | |||
| B/Yokohama/UT2203/2005 | B | D198N | 48.9 | 41.7-58.7 | — | 33.6 | 31.6-35.8 | — | 40.5 | 36.8-44.6 | — |
| B/Yokohama/UT3318/2005 | B | I222T | 30.2 | 27.6-33.0 | — | 20.0 | 16.2-26.4 | — | 68.8 | 63.8-74.1 | — |
a
Amino acids at left mutated to the amino acids at right at the indicated residue numbers, based on N2 NA numbering. Amino acids are described using one-letter symbols. WT, wild type.
b
Mutant/wild-type IC50 ratios are shown. CI, confidence interval; —, not applicable.