FIG. 4.
Accumulation of tenofovir and GS-9148 in fresh human kidney cortex slices. Precision-cut tissue slices were incubated with 5 μM [3H]tenofovir or [14C]GS-9148 in the presence or absence of 500 μM probenecid (PBC). Total (A) and probenecid-sensitive (B) accumulation of the tested nucleotides in tissue slices is shown. Data represent mean ± standard deviation values from a representative experiment performed in triplicate. The accumulation of GS-9148 in human renal tissue was significantly different from that of tenofovir under corresponding conditions. *, P < 0.05; **, P < 0.01.