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. 2008 Nov 10;53(1):150–156. doi: 10.1128/AAC.01183-08

TABLE 1.

Kinetics of hOAT1- and hOAT3-mediated transport of GS-9148 and acyclic nucleotide analogs

Compound	hOAT1^a			hOAT3^a
Compound	K_m (μM)	V_max (pmol/min/10⁶ cells)	V_max/K_m	K_m(μM)	V_max (pmol/min/10⁶ cells)	V_max/K_m
GS-9148	259 ± 102	7.8 ± 0.8	0.03	1,216 ± 8	19.5 ± 14.0	0.016
Cidofovir	58.0 ± 5.7	103 ± 10	1.77	ND^b	ND	ND
Adefovir	23.8 ± 4.2	46.0 ± 4.4	1.93	1,220 ± 740	131.4	0.105
Tenofovir	33.8 ± 3.4	110 ± 12	3.26	770 ± 210	28.7 ± 8.6	0.037

^a

Data represent mean ± standard deviations from two independent experiments performed in duplicate.

^b

ND, not determined. Cidofovir has been shown not to be a substrate for hOAT3.