TABLE 4.
Symptoms and their association with CQ concentrations
| Quartilea | CQ concn (nmol/liter)b 1 day after end of treatment | Frequencyc of the following symptom:
|
Duration of vomiting (days)d | |||
|---|---|---|---|---|---|---|
| Vomiting prior to study entry | Vomiting on day 1 | Diarrhea prior to study entry | Diarrhea on day 1 | |||
| 1 | 185 (0-370) | 13/24 (54) | 6/24 (25) | 13/24 (54) | 10/24 (42) | 1.4 (0.8-2.0) |
| 2 | 662 (395-894) | 14/25 (56) | 6/25 (24) | 15/25 (60) | 16/25 (64) | 1.1 (0.7-1.5) |
| 3 | 1,412 (961-1,820) | 4/24 (17) | 3/21 (14)e | 9/24 (38) | 7/21 (33)e | 0.5 (0-1) |
| 4 | 3,035 (1,870-5,380) | 6/24 (25) | 2/24 (8) | 7/24 (29) | 5/24 (21) | 0.5 (0.2-0.9) |
| Undefined | 2/5 (40%) | 0/5 (0) | 2/3 (40)f | 0/5 (0) | 0.4 (0-1) | |
Defined on the basis of CQ concentrations. The “undefined” group comprised those for whom blood was not available for CQ concentration analysis 1 day after the end of treatment.
The range is given in parentheses.
Given as the number of patients with the symptom/total number of patients (percentage). Using the nonparametric test for trend vomiting prior to study entry (P = 0.006), vomiting on day 1 (P = 0.009), diarrhea prior to study entry (P = 0.03), and diarrhea on day 1 (P = 0.04) were more common in children with lower CQ concentrations.
The 95% confidence interval is given in parentheses. The P value as assessed by the nonparametric test for trend is 0.002.
Data were not available for three children.
Data were not available for two children.