TABLE 2.

Interacting drugs that may alter antifungal blood concentrations

Drug	Interacting drug(s) that may decrease antifungal concn	Interacting drug(s) that may increase antifungal concn
Itraconazole	Antacidsa including aluminum carbonate (basic), aluminum hydroxide, aluminum phosphate, calcium, dihydroxyaluminum aminoacetate, dihydroxyaluminum sodium carbonate, magaldrate, magnesium carbonate, magnesium hydroxide, magnesium trisilicate, sodium bicarbonate; antibiotics including isoniazid, rifabutin, rifampin, rifapentine; antiepileptics including carbamazepine, fosphenytoin, phenytoin; antiretrovirals including darunavir, didanosine, efavirenz, etravirine, nevirapine; H2 blockersa including cimetidine, famotidine, nizatidine, ranitidine, roxatidine; barbituates including phenobarbital; protonpump inhibitorsa including esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole	Antibiotics including clarithromycin; antiretrovirals including amprenavir, darunavir, fosamprenavir, lopinavir, ritonavir
Voriconazole	Antibiotics including rifabutin, rifampin, rifapentine; antiepileptics including carbamazepine, fosphenytoin, phenytoin; antiretrovirals including amprenavir, darunavir, delavirdine, efavirenz, nevirapine, ritonavir, tipranavir; barbituates including alfuzosin, aprobarbital, butabarbital, eterobarb, heptabarbital, hexobarbital, mephobarbital, pentobarbital, phenobarbital, secobarbital	Antiretrovirals including delavirdine, etravirine, fosamprenavir, nelfinavir, nevirapine, saquinavir, tipranavir, efavirenz; oral contraceptives including ethinyl estradiol, norethindrone; proton pump inhibitors including omeprazole
Posaconazole	Antiepileptics including phenytoin; H2 blockers including cimetidine, famotidine, nizatidine, ranitidine, roxatidine; proton pump inhibitors including esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole; gastric motility agent including metoclopramide	Antiarrhythmics including quinidine; antibiotics including rifabutin; antiepileptics including phenytoin; antimalarials including halofantrine; antipsychotics including pimozide; antiretrovirals including etravirine; antihistamines including astemizole(off market), terfenadine (off market); benzodiazepines including midazolam; calcium channel blockers including amlodipine, diltiazem, felodipine, lercanidipine, nifedipine, nisoldipine, nitrendipine, verapamil; ergot alkaloids including dihydroergotamine, ergoloid mesylates, ergonovine, ergotamine, methylergonovine, methysergide; immunosuppressants including cyclosporine, sirolimus, tacrolimus; serotonic receptor antagonists including cisapride (off market); statins including atorvastatin, lovastatin, simvistatin; vinca alkaloids including vinblastine, vincristine, vincristine liposome, vinorelbine

^aImpact the capsule formulation of itraconazole.