FIG. 3.

Mean plus SD interstitial cephalothin (open circles) and unbound plasma cephalothin (closed circles) concentrations for healthy volunteers (a), patient nonburn sites (b), and patient burn sites (c). Error bars for interstitial and unbound plasma cephalothin values are displaced to the left and right, respectively, for 20-min data only. Temporal matching of plasma values to microdialysis sample times was achieved by linear interpolation. The unbound plasma cephalothin value was calculated with prestudy plasma protein binding data for each subject.