TABLE 4.

Summary of mean ratios and 90% CIs for FCZ and TPV

Drug	Comparisona	No. of subjects	Mean ratiob (90% CI) for:
			AUC	Cmax	Cmin
FCZ	FCZ alone (day 6) vs FCZ + sd TPV/r (day 7)	19	0.99 (0.97-1.02)	0.97 (0.94-1.01)	0.98 (0.94-1.02)
	FCZ alone (day 6) vs FCZ + md TPV/r (day 13)	19	0.92 (0.88-0.95)	0.94 (0.91-0.98)	0.89 (0.85-0.92)
TPV	FCZ + md TPV/r (day 13) vs historical controls	20 (68c)	1.50 (1.29-1.73)	1.32 (1.18-1.47)	1.69 (1.33-2.09)

^asd, single-dose; md, multiple-dose. Unless otherwise noted, comparisons are between values for the same subjects on different study days, as indicated in parentheses.

^bParameters are AUC_0-24 and Cp24h (C_min) for FCZ and AUC_0-12 and Cp12h (C_min) for TPV.

^cHistorical controls (n = 68).