TABLE 6.
Summary of mean ratios and 90% CIs for RFB, 25-O-desacetyl-RFB (metabolite), and the total of the parent plus the metabolite, as well as TPV
| Drug(s) | Comparisona | No. of subjects | Mean ratiob (90% CI) for:
|
||
|---|---|---|---|---|---|
| AUC | Cmax | Cmin | |||
| RFB | sd RFB alone (day 1) vs sd RFB + md TPV/r (day 15) | 20 | 2.90 (2.59-3.26) | 1.70 (1.49-1.94) | 2.14 (1.90-2.41) |
| RFB metabolite | sd RFB alone (day 1) vs sd RFB + md TPV/r (day 15) | 20 | 20.71 (17.66-24.28) | 3.20 (2.78-3.68) | 7.83 (6.70-9.14) |
| RFB and metabolite | sd RFB alone (day 1) vs sd RFB + md TPV/r (day 15) | 20 | 4.33 (3.86-4.86) | 1.86 (1.63-2.12) | 2.76 (2.44-3.12) |
| TPV | TPV/r alone (day 14) vs TPV/r + sd RFB (day 15) | 21 | 1.00 (0.96-1.04) | 0.99 (0.93-1.07) | 1.16 (1.07-1.27) |
a
sd, single-dose; md, multiple-dose. Comparisons are between values for the same subjects on different study days, as indicated in parentheses.
b
Parameters are AUC0-∞ for RFB, AUC0-12 for TPV, and Cp12h (Cmin) for RFB and TPV.