TABLE 2.
Serotype | Amphotericin B
|
Flucytosine
|
Fluconazole
|
Posaconazole
|
Voriconazole
|
Isavuconazole
|
||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GM | MIC range | MIC50 | MIC90 | GM | MIC range | MIC50 | MIC90 | GM | MIC range | MIC50 | MIC90 | GM | MIC range | MIC50 | MIC90 | GM | MIC range | MIC50 | MIC90 | GM | MIC range | MIC50 | MIC90 | |
A | 0.25 | 0.06-0.5 | 0.25 | 0.5 | 3.123 | 1-8 | 4 | 4 | 2.32 | 0.25-32 | 2 | 4 | 0.064 | <0.015-0.5 | 0.06 | 0.25 | 0.112 | <0.015-0.5 | 0.06 | 0.25 | 0.036 | <0.015-0.5 | 0.03 | 0.125 |
D | 0.156 | 0.03-1 | 0.125 | 1 | 3.204 | 0.5-8 | 4 | 8 | 1.32 | 0.25-64 | 1 | 8 | 0.021 | <0.015-0.125 | <0.015 | 0.06 | 0.045 | <0.015-0.5 | 0.03 | 0.25 | 0.019 | <0.015-0.06 | <0.015 | 0.03 |
AD | 0.174 | 0.06-0.5 | 0.25 | 0.25 | 4.443 | 0.25-16 | 4 | 8 | 2.269 | 0.25-8 | 2 | 4 | 0.029 | <0.015-0.06 | 0.03 | 0.06 | 0.064 | <0.015-0.25 | 0.06 | 0.125 | 0.018 | <0.015-0.06 | <0.015 | 0.03 |
B | 0.239 | 0.125-1 | 0.25 | 0.25 | 1.66 | 0.06-16 | 2 | 4 | 2.406 | 0.5-32 | 2 | 8 | 0.042 | <0.015-0.25 | 0.03 | 0.125 | 0.098 | <0.015-0.5 | 0.125 | 0.25 | 0.029 | <0.015-0.25 | 0.03 | 0.06 |
C | 0.25 | 0.125-0.5 | 0.25 | 0.5 | 2.997 | 1-8 | 2 | 8 | 2.245 | 0.5-4 | 2 | 4 | 0.038 | <0.015-0.25 | 0.03 | 0.06 | 0.098 | 0.03-0.25 | 0.125 | 0.25 | 0.021 | <0.015-0.125 | <0.015 | 0.03 |
Shown are 28 isolates of serotype A, 25 isolates of serotype D, 33 isolates of the hybrid AD serotype (86 of C. neoformans), 30 isolates of serotype B, and 12 isolates of serotype C (42 of C. gattii).