TABLE 2.
Protection against B. abortus 544 in BALB/c mice immunized with L-Omp16, U-Omp16, L-Omp19, or U-Omp19 protein with IFA
| Vaccine (dose [μg]) | Adjuvant | Log10 CFU of B. abortus 544a | Protection (U) |
|---|---|---|---|
| B. abortus S19 | None | 2.90 ± 0.18b | 2.18 |
| L-Omp16 (10) | IFA | 3.58 ± 0.39b,c | 1.50 |
| U-Omp16 (10) | IFA | 3.11 ± 0.23b | 1.97 |
| L-Omp19 (10) | IFA | 3.65 ± 0.64b,d | 1.43 |
| U-Omp19 (10) | IFA | 3.23 ± 0.65b | 1.85 |
| PBS | IFA | 5.08 ± 0.43d | 0 |
a
The content of bacteria in spleens is represented as the mean log CFU ± standard deviation per group (n = 8 mice per group).
b
Significantly different from PBS-immunized mice (P < 0.01 estimated by Dunnett's test).
c
Significantly different from S19-immunized mice (P < 0.05 estimated by Dunnett's test).
d
Significantly different from S19-immunized mice (P < 0.01 estimated by Dunnett's test).