TABLE 4.
Protection against B. abortus 544 in BALB/c mice immunized with U-Omp16, U-Omp19, or U-Omp16 plus U-Omp19 antigen in IFA
| Vaccine (dose [μg]) | Adjuvant | Log10 CFU of B. abortus 544a | Protection (U) |
|---|---|---|---|
| B. abortus S19 | None | 4.18 ± 0.19b | 2.27 |
| U-Omp16 (10) | IFA | 4.84 ± 0.50b | 1.61 |
| U-Omp19 (10) | IFA | 4.67 ± 0.59b | 1.78 |
| U-Omp16+U-Omp19 (10 each) | IFA | 4.56 ± 0.15b | 1.89 |
| PBS | IFA | 6.45 ± 0.14c | 0 |
a
The content of bacteria in spleens is represented as the mean log CFU ± standard deviation per group (n = 5 mice per group).
b
Significantly different from PBS-immunized mice (P < 0.01 estimated by Dunnett's test).
c
Significantly different from S19-immunized mice (P < 0.01 estimated by Dunnett's test).