TABLE 5.
Protection against B. abortus 544 in BALB/c mice immunized with L-Omp16, U-Omp16, L-Omp19, or U-Omp19 protein adsorbed in aluminum compounds
| Vaccine (dose [μg]) | Adjuvant | Log10 CFU of B. abortus 544a | Protection (U) |
|---|---|---|---|
| B. abortus strain 19 | None | 3.71 ± 0.17b | 2.04 |
| L-Omp16 (10) | Al | 4.35 ± 0.52b | 1.40 |
| U-Omp16 (10) | Al | 4.27 ± 0.66b | 1.48 |
| L-Omp19 (10) | Al | 4.44 ± 1.00b | 1.31 |
| U-Omp19 (10) | Al | 4.48 ± 0.59b | 1.27 |
| U-Omp19 (10) | IFA | 4.05 ± 0.55b | 1.70 |
| PBS | Al | 5.75 ± 0.15c | 0 |
a
The content of bacteria in spleens is represented as the mean log CFU ± standard deviation per group (n = 6 mice per group).
b
Significantly different from PBS-immunized mice (P < 0.01 estimated by Dunnett's test).
c
Significantly different from S19-immunized mice (P < 0.01 estimated by Dunnett's test).