TABLE 6.
Protection against B. abortus 544 or B. abortus 2308 in BALB/c mice immunized orally with U-Omp16 or U-Omp19 protein with CT
| Vaccine | Adjuvant | Protection against oral B. abortus 544
|
Protection against oral B. abortus 2308
|
||
|---|---|---|---|---|---|
| Log10 CFU of bacteriaa | Protection (U) | Log10 CFU of bacteriaa | Protection (U) | ||
| B. abortus strain 19 | None | 4.27 ± 0.22b | 1.20 | ND | |
| B. abortus RB51 | None | ND | 3.90 ± 0.80b | 1.51 | |
| U-Omp16 | CT | 4.32 ± 0.21b | 1.15 | 4.17 ± 0.61d | 1.24 |
| U-Omp19 | CT | 3.81 ± 0.52b | 1.66 | 4.07 ± 0.47d | 1.34 |
| PBS | CT | 5.47 ± 0.02c | 0.00 | 5.41 ± 0.16e | 0.00 |
a
The content of bacteria in spleens is represented as the mean log CFU ± standard deviation per group (n = 5 mice per group). ND, not done.
b
Significantly different from PBS-immunized mice (P < 0.01 estimated by Dunnett's test).
c
Significantly different from strain 19 -immunized mice (P < 0.01 estimated by Dunnett's test).
d
Significantly different from PBS-immunized mice (P < 0.05 estimated by Dunnett's test).
e
Significantly different from RB51-immunized mice (P < 0.01 estimated by Dunnett's test).