FIG. 10.
Subcutaneous infection of SKH1 hairless mice with GAS M49 sortase mutants. (A) GAS strains (2 × 108 CFU) in a mixture with Cytodex beads were used to infect SKH1 mice. Lesion sizes were examined daily for up to 5 days postinfection. The graph shows data from the evaluation at 3 days postinfection. The bars represent average values, and significance values are indicated. n.s., no significant difference, as determined by Student's t test. (B) Representative pictures of mice were taken at 3 days postinfection.