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Binding of the WT and mutant strains to immobilized human matrix proteins. Microtiter plates were coated with the indicated matrix proteins (fibronectin [A], fibrinogen [B], laminin [C], collagen I [D], and collagen IV [E]) and subsequently incubated with the GAS strains. Binding was detected by anti-GAS polyclonal antibody and is represented by the A450. The data represent the mean values ± standard deviations for three independent experiments.
