TABLE 2.
Cytokine levels in uterine homogenates of GD8 Csf1op/op and Csf1op/+ mice following L. monocytogenes infections
| Cytokine/chemokine | Level (pg/g of tissue) in mice of indicated genotype and infection statusa
|
|||||
|---|---|---|---|---|---|---|
| Uninfected
|
24 h p.i.
|
48 h p.i.
|
||||
| Csf1op/+ | Csf1op/op | Csf1op/+ | Csf1op/op | Csf1op/+ | Csf1op/op | |
| Th1 cytokines | ||||||
| IL-6 | 248.5 ± 30.4 | 420.6 ± 151.0 | 661.9 ± 172.6 | 1,445.5 ± 521.7 | 513.6 ± 237.9 | 1,812.3 ± 641.8* |
| IFN-γ | 581.9 ± 129.6 | 2,615.7 ± 796.8* | 2,222.1 ± 648.1 | 3,954.2 ± 1,395.1 | 1,775.2 ± 493.4 | 2,040.2 ± 591.6 |
| TNF-α | 43.9 ± 16.1 | 81.7 ± 15.9* | 61.3 ± 8.1 | 185.2 ± 117.9 | 117.2 ± 27.1 | 1,662.5 ± 383.7** |
| Th2 cytokines | ||||||
| IL-4 | ND | ND | ND | ND | ND | ND |
| IL-5 | ND | ND | ND | ND | ND | ND |
| IL-10 | 5,664.5 ± 1,270.1 | 13,259.5 ± 3,811.0* | 4,892.1 ± 1,532.9 | 10,620.2 ± 3,760.7 | 6,902.0 ± 559.1 | 8,900.6 ± 2,427.4 |
| Chemokines | ||||||
| KC | 733.7 ± 328.9 | 600.9 ± 106.7 | 1,456.1 ± 174.8 | 1,967.1 ± 650.6 | 1,517.2 ± 615.0 | 5,493.9 ± 1,642.6* |
| IL-17A | 391.5 ± 108.8 | 607.9 ± 133.1 | 244.0 ± 68.5 | 688.1 ± 226.2* | 504.4 ± 123.6 | 497.2 ± 143.5 |
a
*, P < 0.05; **, P = 0.002 (Student's t test); ND, not detectable.