TABLE 2.
Naip5 amino acid polymorphisms in B6, MOLF, and A/J mice
| Amino acid no. | Exon | Polymorphic residuea
|
||
|---|---|---|---|---|
| B6 | MOLF | A/J | ||
| 92 | 3 | R | R | R |
| 144 | 3 | R | R | R |
| 234 | 5 | E | K | E |
| 368 | 9 | T | M | T |
| 472 | 11 | T | A | A |
| 496 | 11 | Y | Y | N |
| 512 | 11 | D | D | G |
| 514 | 11 | G | G | E |
| 517 | 11 | N | N | K |
| 533 | 11 | V | A | A |
| 538 | 11 | S | I | I |
| 647 | 11 | A | A | T |
| 692 | 11 | S | S | P |
| 755 | 11 | V | V | M |
| 855 | 11 | S | T | S |
| 952 | 11 | S | T | S |
| 1021 | 11 | M | I | M |
| 1092 | 12 | E | D | D |
| 1116 | 12 | N | D | D |
| 1123 | 12 | R | G | G |
| 1137 | 12 | Q | R | Q |
| 1140 | 12 | T | R | T |
| 1241 | 15 | V | V | I |
| 1275 | 15 | D | D | N |
a
Naip5 amino acids in bold were originally predicted to correlate with permissiveness of mouse macrophages for L. pneumophila growth (41). Residues which are unique to A/J Naip5 compared to those of B6 or MOLF Naip5 are underlined.