TABLE 5.
Immunogenicity of a single dose and of two doses of H6 ca viruses in micea
| Test antigen used in NtAb assay | Geometric mean titer of serum NtAb in mice immunized withb:
|
|||||
|---|---|---|---|---|---|---|
| dk/HK/77 ca
|
ma/Alb/85 ca
|
tl/HK/97 ca
|
||||
| 1 Dose | 2 Doses | 1 Dose | 2 Doses | 1 Dose | 2 Doses | |
| dk/HK/77 wt | 214 | 528 | 44 | 29 | 27 | 85 |
| ma/Alb/85 wt | 10c | 10 | 314 | 3,044 | 10 | 15 |
| tl/HK/97 wt | 10 | 10 | 10 | 10 | 94 | 543 |
| qu/HK/99 wt | 10 | 10 | 10 | 10 | 86 | 388 |
a
Groups of eight mice were inoculated i.n. with 106 TCID50 of H6 ca viruses. NtAb titers were determined for sera collected 4 weeks after the first dose and 2 weeks after the second dose of vaccination by microneutralization assay in MDCK cells.
b
Antibody titers against homologous viruses are underlined.
c
Undetectable titer was assigned as 10.