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Treatment with TNF plus IFN-β results in “synergy by cooperative action.” (A) Graph depicting the 236 human genes upregulated by TNF alone or TNF plus IFN-β; (B) graph depicting the 274 human genes upregulated by either IFN-β alone or TNF plus IFN-β. Each gene is shown twice on each graph. The fold change induced by the single cytokine alone is shown in blue, while the fold change induced by the combination of both cytokines is shown in red.
