TABLE 2.
Classes of highly upregulated genes
| Gene class and gene | Cytokine (fold increase)
|
Function | ||
|---|---|---|---|---|
| TNF+IFNβ | TNF | IFN-β | ||
| Distinct genes | ||||
| CCL5 | 140 | 0 | 0 | Cytokine |
| CD38 | 112 | 0 | 0 | Signaling |
| DHX58 | 101 | 0 | 0 | Antiviral |
| APOL1 | 82 | 0 | 0 | Lipid metabolism |
| VCAM1 | 66 | 0 | 0 | Immune activation |
| GBP4 | 66 | 0 | 0 | GTP exchange |
| CR1 | 61 | 0 | 0 | Complement |
| DMRTAI | 52 | 0 | 0 | Development |
| Partially distinct genes (TNF) | ||||
| IL-8 | 1,575 | 1,411 | 0 | Cytokine |
| IL-32 | 500 | 212 | 0 | Cytokine |
| CCL2 | 360 | 167 | 0 | Cytokine |
| BIRC3 | 248 | 128 | 0 | Cytokine |
| CXCL2 | 234 | 181 | 0 | Cytokine |
| C8orf4 | 215 | 97 | 0 | Apoptosis |
| 116 | 191 | 118 | 0 | Cytokine |
| CXCL1 | 143 | 112 | 0 | Cytokine |
| CXCLS | 72 | 211 | 0 | Unknown |
| CXCL6 | 9 | 59 | 0 | Cytokine |
| Partially distinct genes (IFN) | ||||
| CXCL11 | 2,004 | 0 | 69 | Antiviral |
| RSAD2 | 1,065 | 0 | 679 | Immune activation |
| BST2 | 867 | 0 | 410 | Unknown |
| TNFSF13B | 620 | 0 | 120 | Receptor |
| 15G20 | 330 | 0 | 117 | Cytokine |
| IF127 | 280 | 0 | 139 | Antiviral |
| NPBWR1 | 205 | 0 | 121 | Unknown |
| ANGPTLI | 168 | 0 | 69 | Immune activation |
| IF144L | 163 | 0 | 107 | Unknown |
| TLR3 | 152 | 0 | 79 | Cytokine |
| BATF2 | 131 | 0 | 54 | Unknown |
| LOC727996 | 124 | 0 | 64 | Transcription |
| IL18BP | 94 | 0 | 51 | Cytokine |
| Shared genes | ||||
| CXCL10 | 954 | 6 | 4 | Cytakine |
| OAS1 | 606 | 6 | 397 | Antiviral |
| IFIT2 | 394 | 4 | 186 | Unknown |
| MX2 | 337 | 6 | 248 | Unknown |
| IL-411 | 293 | 51 | 25 | Antigen presentation |
| TNFAIP6 | 274 | 17 | 3 | Adhesion |
| OAS2 | 185 | 6 | 137 | Antiviral |
| IFIH1 | 185 | 9 | 59 | Antiviral |
| EPSTI1 | 150 | 7 | 67 | Unknown |
| LOC129607 | 139 | 4 | 95 | Unknown |
| IFIT1 | 137 | 3 | 106 | Unknown |
| GCH1 | 136 | 13 | 4 | Metabolism |
| HERC6 | 132 | 5 | 84 | Ubiquitination |
| ICAM1 | 130 | 41 | 4 | Immune activation |
| C15orf48 | 119 | 23 | 7 | Unknown |
| CT55 | 118 | 15 | 21 | Antigen presentation |
| CFB | 115 | 3 | 14 | Complement |
| APOL3 | 104 | 4 | 38 | Intracellular trafficking |
| PSMB9 | 102 | 6 | 76 | Proteasome |
| GBP5 | 87 | 7 | 9 | GTP exchange |
| IFIT3 | 60 | 3 | 40 | Unknown |
| MX1 | 56 | 5 | 52 | Antiviral |
| DDX58 | 54 | 2 | 24 | Antiviral |
| OAS3 | 51 | 4 | 36 | Antiviral |
| CCL7 | 51 | 15 | 5 | Cytokine |