TABLE 1.
Results of mutations in the NwV coat protein
| Mutation(s) | Assembly | LCC | Proteolytic kineticsa | Residual pKab
|
|
|---|---|---|---|---|---|
| Procapsid | Capsid | ||||
| Glu73Gln | Yes | Native-like | Aberrant | (Glu73) 2.44-5.24 | (Glu73) 1.74-3.92 |
| Asp124Asn | No | (Asp124) 2.4-4.44 | (Asp124) 1.98-8.10 | ||
| Glu278Gln | Yes | Native-like | Aberrant | (Glu278) 4.5 | (Glu278) 6.27-6.73 |
| Glu442Gln | Yes | Native-like | Native-like | (Glu442) 5.89-6.40 | (Glu442) 8.03-9.58 |
| Asp87Asn/Asp124Asn | No | (Asp87) 2.22-9.31 | (Asp87) 6.49-12.84 | ||
a
See Fig. 7.
b
A complete list of the pKa values for all ionizable residues is available from the authors.