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Levels of challenge virus replication in the nervous system. Mice were immunized with the low dose of 5BlacZ or 5B86 or with control supernatant and challenged i.vag. with HSV-2 1 month later. After 5 days, mice were sacrificed, the indicated regions of the CNS were dissected and homogenized, and the virus titer in them was determined by standard plaque assay. Data represent the geometric mean ± SEM for six samples per group. **, P value of 0.0049 for 5B86 compared with 5BlacZ.
