FIG. 5.
VSV titers in the brain following intranasal administration. Three groups of five BALB/c mice were infected intranasally with 5 × 107 PFU VSV/GFP, ΔM51-VSV/GFP, or VSV/FAST. On day 6 brains were collected, and tissue titers were determined by duplicate plaque assays. The VSV/GFP-infected brains showed highly variable tissue titers with two brains near the limit of detection and one falling below this limit. The VSV/FAST-infected brains all showed similar, high tissue titers. Although the mean titer for the ΔM51-VSV-infected brains was significantly different than the other groups (one-way analysis of variance, P < 0.05), the mean titers for the VSV/GFP- and VSV/FAST-infected brains were not significantly different at this time point (one-way analysis of variance, P > 0.05). However, these two groups showed significantly different variances (P = 0.0092).