FIG. 6.

Biodistribution of viruses. VSV/FAST enters the brains of mice more rapidly after intravenous infection. In two independent experiments mice were injected intravenously with 2 × 10⁸ PFU of either VSV/GFP or VSV/FAST, and tissues from three animals were analyzed for each time point. Although in most tissues the titers measured were similar between these two viruses (i.e., the spleen shown here and data not shown), the VSV/FAST virus generated higher titers in brains and thyroid/cervical lymph nodes at the 48 h time point while showing lower titers in the lung at 24 h. At the 96-h time point virus was only detectable in brains for both viruses. Mean titers ± the SEM are shown. An asterisk (*) indicates a statistically significant difference (P < 0.05, two-tailed t test).