TABLE 3.
Predicted reaction knockouts that affect the production of LPS without affecting the production of other biomass componentsa
| Reaction | Protein ID | Gene | Description |
|---|---|---|---|
| GMAND | PG1288 | gmd | GDP-d-mannose dehydratase |
| KDOPP | PG0658 | 3-Deoxy-manno-octulosonate-8-phosphatase | |
| GFUCS | PG1289 | fcl | GDP-l-fucose synthase |
| PMANM | PG1094, PG2010 | pgm | Phosphomannomutase |
| MAN6PI | PG0468 | manA | Mannose-6-phosphate isomerase |
| MAN1PT2r | PG2215 | manC | Mannose-1-phosphate guanylyltransferase (GDP) reversible |
| UDPG4E | PG0347 | galE | UDP-glucose 4-epimerase |
| KDOCT | PG1815 | kdsB | 3-Deoxy-manno-octulosonate cytidylyltransferase |
a
Here we include only reactions associated with a specific P. gingivalis protein. For each reaction, we list the KEGG protein identification (ID) and gene name, as well as a description of the enzyme function. The entry in boldface is a knockout for which an effect has been reported in the literature (59).