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Effect of hypercholesterolemic diet and exercise training on adenosine-mediated concentration-response curves in porcine coronary arterioles. Adenosine-mediated vasodilatation was significantly attenuated in arterioles from hypercholesterolemic (HC) compared with control (NC) animals in both sedentary (Sed; A) and exercise-trained (Ex; B) groups. Arterioles were preconstricted with endothelin-1. Values are means ± SE of the number of animals in parentheses. *P ≤ 0.05.
