Fig. 2.

Effect of Kv channel blockade on adenosine-mediated concentration-response curves in porcine coronary arterioles. Adenosine-mediated vasodilatation was significantly attenuated by the classic Kv channel inhibitor 4-aminopyridine (4-AP) in arterioles from both NC-Sed (A) and NC-Ex (B) animals. In contrast, Kv channel blockade did not significantly alter adenosine-induced dilatation in coronary arterioles from hypercholesterolemic pigs of sedentary (HC-Sed; C) and exercise-trained (HC-Ex; D) groups. A subset of data in 2C has been published previously (19). Arterioles were preconstricted with endothelin-1. Values are means ± SE of the number of animals in parentheses. *P ≤ 0.05.