Fig. 5.

Effect of hypercholesterolemic diet on forskolin-mediated concentration-response curves in porcine coronary arterioles. A: forskolin-mediated vasodilatation was significantly attenuated in arterioles from HC-Sed compared with NC-Sed. Forskolin-mediated vasodilatation was significantly attenuated by 4-AP and TEA in arterioles from NC-Sed (B) but not HC-Sed (C) animals. Arterioles were preconstricted with endothelin-1. Values are means ± SE of the number of animals in parentheses. *P ≤ 0.05.