TABLE 1.
Genotypic analysis of embryos derived from intercrosses between Rb+/−; E2f3a+/− mice and either Rb+/−; E2f3a+/− or Rb+/−; E2f3a−/− micea
| Genotype | No. of embryos at day:
|
|||||||
|---|---|---|---|---|---|---|---|---|
| E13.5
|
E15.5
|
E16.5
|
E17.5
|
|||||
| Found | Expected | Found | Expected | Found | Expected | Found | Expected | |
| Rb+/+ | ||||||||
| 3a+/+ | 6 | 9 | 12 | 9 | − | − | 2 | 1 |
| 3a+/− | 20 | 15 | 15 | 13 | 6 | 3 | 3 | 3 |
| 3a−/− | 7 | 9 | 9A | 9 | 7 | 5 | 4 | 6 |
| Rb+/− | ||||||||
| 3a+/+ | 11 | 13 | 16 (1) | 19 | − | − | 5 | 3 |
| 3a+/− | 33 (1) | 31 | 31 (1) | 26 | 5 | 7 | 4 | 6 |
| 3a−/− | 16 (1) | 22 | 11 | 18 | 8 | 8 | 12 | 13 |
| Rb−/− | ||||||||
| 3a+/+ | 4 (2) | 7 | 0 (9)B | 9 | − | − | 0 (1) | 1 |
| 3a+/− | 14 (5) | 15 | 2 (9) | 13 | 0 | 3 | 0 (2) | 3 |
| 3a−/− | 6 (2) | 9 | 5 (3)C | 9 | 2 (4) | 5 | 1 (7) | 6 |
| Total | 128 | 124 | 32 | 41 | ||||
a
All embryos, including dead embryos, were genotyped. The numbers of genotyped dead fetuses are indicated in parentheses. −, no embryos with this genotype were found. Chi-square analysis was used for association (superscript capital letters): A, P > 0.1 compared to Rb+/+ mice; B, P < 0.005 compared to Rb+/+ mice; C, P < 0.005 compared to Rb−/− mice.