TABLE 1.
Mre11ATLD1/ATLD1 Prkdcscid/scid mutant data
| Genotype of father | Genotype of mother | Time point of assessment | Total no. of embryos | Total no. of pups | Expected no. of double mutants | Observed no. of double mutants | P valueb |
|---|---|---|---|---|---|---|---|
| Mre11+/ATLD1Prkdcscid/scid | Mre11+/ATLD1Prkdcscid/scid | E10.5 | 15 | 3.75 | 3a | ||
| E3.5 | 10 | 2.5 | 3 | ||||
| Mre11+/ATLD1Prkdc+/scid | Mre11+/ATLD1Prkdc+/scid | After birth | 203 | 12.7 | 0 | 2.0 × 10−6 | |
| Mre11+/ATLD1Prkdcscid/scid | Mre11+/ATLD1Prkdc+/scid | After birth | 35 | 4.4 | 0 | 9.4 × 10−3 | |
| Mre11+/ATLD1Prkdcscid/scid | Mre11+/ATLD1Prkdcscid/scid | After birth | 62 | 15.5 | 0 | 1.8 × 10−8 |
a
Embryos were partially reabsorbed or were abnormal or runted.
b
P values are based on binomial distribution.