FIG. 1.

The mouse and human AOX gene clusters and XOR locus. (Top) The lengths and relative positions of the four mouse AOX genes (Aox1, Aoh1, Aoh2, and Aoh3) mapping to chromosome 1 and the single XOR gene (Xor) on chromosome 17, along with their exon composition, are illustrated. (Bottom) The lengths and relative positions of the only functionally active human AOX gene (AOX1), the two pseudogenes AOH1* and AOH3* on chromosome 2q, and the XOR gene on chromosome 2p are shown. The exons present in the active mouse and human genes are indicated. The exons showing sequence similarity with the corresponding mouse orthologous genes are indicated above the two human pseudogenes. Chr, chromosome.