TABLE 3.
List of genes whose expression is significantly perturbed in the skin of Aoh2−/− micea
| Gene category | Accession no. | Gene name | logRb | P valuec |
|---|---|---|---|---|
| Downregulated genes | AK147421 | Acsl6 | −1.81 | 1.74E-03 |
| AK050118 | Igf1 | −1.44 | 4.00E-03 | |
| NM_033174 | Snurf | −1.30 | 3.24E-03 | |
| NM_013744 | Zfp354b | −1.30 | 4.83E-03 | |
| NM_022881 | Rgs18 | −1.27 | 2.60E-03 | |
| NM_145713 | Hist1h1d | −1.27 | 3.99E-03 | |
| NM_011935 | Esrrg | −1.27 | 7.15E-04 | |
| NM_011670 | Uchl1 | −1.23 | 1.87E-03 | |
| AY590892 | Dmxl1 | −1.19 | 2.02E-03 | |
| NM_011994 | Abcd2 | −1.17 | 1.14E-03 | |
| NM_030143 | Ddit4l | −1.12 | 3.38E-03 | |
| NM_026167 | Klhl13 | −1.08 | 1.92E-03 | |
| NM_009808 | Casp12 | −1.05 | 4.50E-03 | |
| AK029536 | Ttc18 | −1.03 | 4.98E-03 | |
| Downregulated unknown genes | NM_172419 | 9030612E09Rik | −1.55 | 3.27E-03 |
| BC058715 | C030002C11Rik | −1.39 | 3.26E-03 | |
| XM_126361 | 5730455P16Rik | −1.26 | 4.22E-03 | |
| NM_027564 | 4921507P07Rik | −1.23 | 4.50E-03 | |
| NM_001039244 | LOC633640 | −1.20 | 2.58E-03 | |
| NM_172513 | BC049806 | −1.18 | 1.26E-03 | |
| NM_172392 | BC028265 | −1.18 | 4.27E-03 | |
| AK047247 | AK047247 | −1.15 | 2.40E-03 | |
| XM_914237 | LOC638271 | −1.14 | 1.65E-03 | |
| AK052002 | AK052002 | −1.08 | 1.84E-03 | |
| Upregulated genes | AK048375 | Mtap2 | 3.80 | 8.07E-04 |
| AK089714 | AK089714 | 3.04 | 1.32E-03 | |
| AK018004 | Rps18 | 2.71 | 3.74E-04 | |
| XM_147798 | Slc4a7 | 2.45 | 1.44E-03 | |
| XM_900817 | Nrg1 | 2.08 | 1.17E-03 | |
| NM_010600 | Kcnh1 | 2.04 | 4.59E-03 | |
| AK045806 | Erbb2ip | 2.04 | 2.40E-03 | |
| NM_175661 | Hist1h2af | 2.03 | 2.32E-03 | |
| AK086235 | Wdr45l | 1.98 | 1.43E-03 | |
| AK031473 | Polr3f | 1.97 | 3.98E-03 | |
| AK090248 | Sec63 | 1.97 | 2.65E-03 | |
| NM_010110 | Efnb1 | 1.86 | 4.35E-03 | |
| AK080436 | Hmgn1 | 1.75 | 1.36E-03 | |
| NM_181820 | Tmc4 | 1.74 | 4.05E-03 | |
| AK172914 | Lpgat1 | 1.67 | 1.55E-03 | |
| NM_178182 | Hist1h2ai | 1.67 | 1.52E-03 | |
| NM_178085 | Rab6ip2 | 1.63 | 3.83E-03 | |
| XM_132817 | Ankrd26 | 1.58 | 4.60E-03 | |
| AK040105 | A430061O12Rik | 1.56 | 1.03E-03 | |
| NM_016871 | Tomm40 | 1.51 | 3.93E-03 | |
| TC1469302 | TC1469302 | 1.49 | 2.49E-03 | |
| AK044468 | Vps29 | 1.48 | 2.53E-03 | |
| AK082550 | AK082550 | 1.45 | 4.52E-03 | |
| AK037501 | Trpc4ap | 1.45 | 4.38E-03 | |
| AK014632 | Mrpl38 | 1.44 | 5.89E-04 | |
| BC006644 | Smg6 | 1.39 | 3.00E-03 | |
| NM_028950 | Nsun6 | 1.39 | 3.68E-03 | |
| XM_484715 | Sft2d3 | 1.36 | 2.09E-03 | |
| AK045956 | Krit1 | 1.35 | 4.27E-03 | |
| NM_011119 | Pa2g4 | 1.33 | 1.76E-03 | |
| AK047982 | Rtn4 | 1.33 | 1.60E-03 | |
| NM_175284 | Fzd10 | 1.28 | 2.21E-03 | |
| NM_172266 | Lpgat1 | 1.27 | 1.77E-03 | |
| TC1414359 | TC1414359 | 1.22 | 3.88E-03 | |
| NM_153787 | Bclaf1 | 1.20 | 2.87E-03 | |
| XM_484715 | Sft2d3 | 1.19 | 4.93E-03 | |
| AK084917 | Rad23b | 1.12 | 3.16E-03 | |
| NM_008001 | Fgd1 | 1.12 | 1.86E-03 | |
| NM_010792 | Mettl1 | 1.11 | 1.39E-03 | |
| NM_016775 | Dnajc5 | 1.05 | 1.57E-03 | |
| NM_029001 | Elovl7 | 1.05 | 3.54E-03 | |
| NM_009726 | Atp7a | 1.02 | 4.27E-03 | |
| NM_018754 | Sfn | 1.01 | 2.64E-03 | |
| NM_027026 | Lrrc46 | 1.00 | 3.95E-03 | |
| Upregulated unknown genes | XM_912173 | LOC636687 | 2.83 | 1.26E-03 |
| BC090402 | BC090402 | 2.30 | 1.71E-03 | |
| AK081758 | B930068K11Rik | 2.13 | 3.02E-03 | |
| TC1477839 | TC1477839 | 2.13 | 4.32E-03 | |
| TC1522673 | TC1522673 | 1.96 | 3.32E-03 | |
| AK220358 | 9130404D08Rik | 1.79 | 1.71E-03 | |
| BC028769 | 6030458C11Rik | 1.71 | 3.16E-03 | |
| AK084691 | AK084691 | 1.68 | 4.50E-03 | |
| TC1533348 | TC1533348 | 1.65 | 1.14E-03 | |
| AK164650 | 5530601H04Rik | 1.59 | 1.54E-03 | |
| AK014787 | 4833428M15Rik | 1.59 | 3.48E-03 | |
| ENSMUST00000024982 | ENSMUST00000024982 | 1.58 | 1.27E-03 | |
| AK049426 | AK049426 | 1.48 | 4.37E-03 | |
| NM_177271 | E130306M17Rik | 1.46 | 4.24E-03 | |
| AK081612 | 9130404D08Rik | 1.46 | 3.08E-03 | |
| AK011948 | AK011948 | 1.43 | 9.84E-04 | |
| AK036075 | AK036075 | 1.42 | 2.90E-03 | |
| AK013536 | 3010026O09Rik | 1.38 | 2.09E-03 | |
| NM_027561 | 4632415L05Rik | 1.31 | 1.31E-03 | |
| XM_923365 | D430007A19Rik | 1.23 | 3.08E-03 | |
| NM_001012326 | LOC433762 | 1.18 | 1.17E-03 | |
| AK049476 | C430014M02Rik | 1.09 | 2.81E-03 | |
| XM_130548 | 2610101J03Rik | 1.04 | 3.13E-03 | |
| AK079466 | A030007N12Rik | 1.00 | 2.67E-03 |
a
List of the genes significantly up- or downregulated in the skin of Aoh2−/− mice after analysis of the gene expression microarray results (P < 0.05; >2-fold change).
b
logR is the log2 ratio (Aoh2−/− versus WT mice) of the mean values for four individual pairs of animals.
c
P values indicate the statistical significance of each determination.