Figure 3.

Turnover of eGFP⁺ cells in the corneal stroma of at 2, 4 and 8 weeks post-reconstitution. In all three anatomical regions of the cornea, there was a gradual increase in the density of donor eGFP⁺ cells in the corneal stroma (a), with the greatest difference in turnover between 2 and 8 weeks occurring in the central cornea. Dotted lines depict the normal mean density of eGFP⁺ cells in the specific regions of the corneal stroma. The total density of eGFP⁺ cells throughout the cornea, calculated by pooling all the regions, clearly illustrates a gradual increase from 2 to 8 weeks (b). The turnover rate increased from approximately 25% at 2 weeks to 75% at 8 weeks (c). Each data point represents one animal.