Distribution of sidechain configurations for Tyr97 and Trp100 of 1dba. Brown configurations are from the native structure, and cyan configurations are from the holo structure. Grey sidechains are distinct configurations from a sidechain trajectory at the given conditions. (a) Tyr97 at 300 K, protocol A. (b) Tyr97 at 600 K, protocol A. (c) Tyr97 at 900 K, protocol A. (d) Tyr97 at 300 K, protocol B. (e) Tyr97 at 600 K, protocol B. (f) Tyr97 at 900 K, protocol B. (g) Trp100 at 300 K, protocol A. (h) Trp100 at 600 K, protocol A. (i) Trp100 at 900 K, protocol A. (j) Trp100 at 300 K, protocol B. (k) Trp100 at 600 K, protocol B. (l) Trp100 at 900 K, protocol B.