. 2008 Dec 4;5:22. doi: 10.1186/1476-9255-5-22

Table 1.

In vitro inhibitory effects of SB-203580 and VX-745 on p38 and cytokine release

IC₅₀(nM)
Compound	P38α^a	TNFα^b(THP-1 cells)	TNFα^c(PBMC)	IL-1β^c(PBMC)

SB-203580	136 ± 64	72 ± 15	16 ± 6	20 ± 8

VX-745	35 ± 14	29 ± 14	14 ± 8	15 ± 4

^aHuman p38α kinase was assayed using ATF2.

^bTNFα release from the human monocytic cell line THP-1 was measured by ELISA 4 h after stimulation with LPS.

^cTNFα and IL-1β release from human peripheral blood mononuclear cells was measured by ELISA 16 h after stimulation with LPS. All data are expressed as the mean ± S.D.