Table 1.
Pertinent clinical data and gene expression levels in normal females and in untreated and treated female patients with Graves' disease. TRAk, TSH receptor autoantibodies in serum. Heg = a poly A(−) RNA transcript gene related to thyroid receptor autoantibodies.
| Age Years Mean range | Sex ♀ | TRAk Median ± range IU/l | Heg amol/µg total RNA | Heg amol/µg DNA | Nucks amol/µg total RNA | Nucks amol/µg DNA | CD14 amol/µg total RNA | CD14 amol/µg DNA | Duration Months Median range | |
|---|---|---|---|---|---|---|---|---|---|---|
| Normal subjects | 44 | 10 | 0·35 ± 0·01 | 0·15 ± 0·01 | 3·06 ± 0·17 | 1·26 ± 0·07 | 77 ± 12 | 30 ± 3 | ||
| 27–59 | ||||||||||
| Graves' disease | 48 | 16 | 10·9 | 0·29 ± 0·01 | 0·13 ± 0·01 | 2·06 ± 0·08 | 0·94 ± 0·07 | 62 ± 8 | 29 ± 4 | 0 |
| Untreated patients | 35–67 | 2·8–90 | ||||||||
| Graves' disease | 42 | 15 | 7 | 0·32 ± 0·02 | 0·14 ± 0·01 | 2·4 ± 0·13 | 0·97 ± 0·07 | 73 ± 14 | 28 ± 5 | 13 |
| Treated patients | 28–52 | 0·5–114 | 1–19 |