. Author manuscript; available in PMC: 2008 Dec 31.

Published in final edited form as: Arch Immunol Ther Exp (Warsz). 2007 Mar 9;55(2):61–75. doi: 10.1007/s00005-007-0009-7

Table 1.

Known mechanisms of ROCK activation and inactivation

Regulators	Site of interaction on ROCK	Effects	Ref
Rho	interacts with RBD, ROCK1 and ROCK2	activation	[54,73,82]
AA	interacts with the PH domain, ROCK2	activation	[29,35]
SPC	interacts with the PH domain, ROCK2	activation	[126]
PI3,4,5P₃, PI4,5P₂	interact with the PH domain, ROCK2 only	activation	[151]
Gem, Rad	interact with the coiled-coil domain, ROCK1 and ROCK2	inactivation	[145]
Caspase 3	cleaves at DETD1113, ROCK1 only	activation	[16,119]
RhoE	interacts between amino acids 1-420, ROCK1 only	inactivation	[101,112]
STK15	phosphorylates at serine residues between amino acids 726 -1,034, ROCK1	inactivation	[25]
Granzyme B	cleaves at IGLD1131, ROCK2 only	activation	[118]
Caspase 2	cleavage site is not known, ROCK2 only	activation	[117]
Raf-1	site of interaction is not known, ROCK2 only	inactivation	[107]
p21^Cip1/WAF1	site of interaction is not known, ROCK2	inactivation	[81]